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About HP Ink 78 and 45 Cartridges 4-Pack

Bundle up and save a lot more with our 4-pack of HP ink 78 and 45 cartridges!

CompAndSave offers affordable replacement HP 45 78 ink cartridge combo pack that boasts genuine-like quality and satisfaction. This cartridge perfectly works as the original HP cartridges without fail!

  • BUMP UP YOUR SAVINGS. Want to enjoy even bigger savings? Purchase our value pack, like the HP 45 HP 78 ink cartridge combo pack of 4. Included are 3 x HP 45 black ink cartridge (51645A) and 1 x HP 78 tri-color ink cartridge (C6578AN).
  • MADE WITH PRECISION. Every cartridge we sell is proven and tested to work like OEM cartridges, with a tested shelf-life of at least 20 months. Our HP ink 78 and 45 cartridges is professionally engineered to ensure that CompAndSave's cartridges will function like original ones—from installation to print quality.
  • LOW PRICE, SAME QUALITY. The print capacity and quality of CompAndSave's cartridges match the original HP printer cartridges, but at a lesser price without sacrificing the quality. Purchasing an HP 78 and 45 ink cartridges from us means you get to save $163.16 (66% off retail price), talk about getting the most of your money!
  • NEXT DAY SHIPPING. HP 45 78 ink cartridge combo pack orders placed before 2:00 p.m. PST will be shipped out the same business day. Visit our Shipping Policy for more information.
  • FREE SHIPPING. For U.S. orders, checking out $50 or more means the shipping fee is on us!
  • ECO-FRIENDLY SOLUTIONS. Did you know that our replacement or remanufactured cartridges are environmentally friendly? Instead of throwing away empty original HP cartridges, our manufacturer meticulously recycles them to function exactly like the originals. By purchasing our replacement HP ink 78 and 45 cartridges, you will not only save a ton of money, but you will also be helping to preserve the environment.
  • SATISFACTION GUARANTEE. We offer a FULL refund within ten days based on the delivery date of your CompAndSave products. We even issue refunds and store credits up to 365 days from purchase. That is how confident we are in the quality of our replacement HP ink cartridges 45 78. Check our Return Policy for more details.
  • WILL NOT VOID PRINTER WARRANTY. Using replacement, compatible, or remanufactured printer cartridges will never void your printer warranty. To know more, check our Ink Knowledge Base page or contact us for any further questions.

Go ahead and find your printer from the compatible printer list for HP ink 78 and 45 cartridges provided below. Take advantage of our great prices for HP 45 78 ink cartridge combo pack today. SAVE more now!

HP Ink 78 and 45 Cartridges FAQs

Can I use a different number ink cartridge for my HP printer?

No, you can't. Each HP printer has a designated ink cartridges for them. These cartridges has different size, yield and compatibility and your printer will not recognize the cartridge if its the wrong one. Using a wrong ink cartridge on your HP printer might cause some issues. To know the model number of the cartridge your printer is using, you may check the user's manual that came with your printer. You may also check the existing cartridge that is installed in your printer, in front or on the side is a label or sticker with the model number which usually consists of alphanumeric characters. If you need help finding the right cartridge for your printer, you can check our find my ink guide, and you will be redirected to the right page.

Do all HP ink cartridges fit all printers?

No, not all HP ink cartridges have the same size, copper contacts, fittings, and printer compatibility. Installing the wrong ink cartridge model in your printer can damage your machine, so make sure to only install the ink cartridge intended for your printer to avoid this kind of issue. For more information, you can check our find my ink guide, and you will be redirected to the right page.

Can I refill HP ink cartridges?

Yes, you can refill genuine HP cartridges. You just need to have the right instruction and tools in order to do so. But to avoid issues, we highly suggest you replace any empty ink cartridges. CompAndSave offers a wide variety of printer ink cartridges at a much lesser price without compromising its quality. Our cartridges are manufactured to meet or exceed the OEM specifications, which will save you from all the trouble of going through the process of refilling an ink cartridge. If you need a step-by-step instruction on how to refill an ink cartridge, check our ink refill guide, and you will be redirected to the right page.

How to install HP 45 and HP 78 ink cartridges?

The installation procedure for HP 45 and HP 78 ink cartridges varies on the printer model that you have. Some printers will require a different or special procedure that other models will not require. So, with that being said, we recommend looking for your printer model below in the compatible printers field. Click the printer model, and you will be redirected to another page with the exact installation procedure for your printer. For more information, you may check our ink installation guide, and you will be redirected to the right page. Please note that this instruction is just a general procedure that is applicable to most printers.


All ink & toner come with a one-year 100% satisfaction guarantee.
Our products will never void your printer's warranty.

HP Ink 78 and 45 Cartridges 4-Pack Specifications

SKU ZINK-HP-51645A-C6578DN-COMBO4
Product Type INK
Replace OEM # 51645A, C6578AN
Colors Black, Tri-color
Product Capacity Standard
Ink Volumes Black: 42 ml | Tri-color: 19 ml
Approximate Page Yields Black: 930 | Tri-color: 560
Cost per page 2.71 cents
Number of pieces 4
Product Shelf Life 18-24 months

HP Ink 78 and 45 Cartridges Compatible Printers

Replacement HP Ink 78 and 45 Cartridges 4-Pack Reviews

7 Customer Reviews
4.6 out of 5 stars
86% Recommend
this product
5 stars 5
4 stars 1
3 stars 1
2 stars 0
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Replacement HP Ink 78 and 45 Cartridges 4-Pack: 3 HP 45 Black, 1 HP 78 Tricolor
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  • Product worked as expected
    Oct 11, 2023
    Verified Buyer
    Arrived quickly
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  • Oct 10, 2022
    Verified Buyer
    Works well & looks good in print.
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  • Jun 23, 2022
    Verified Buyer
    Love that we were able to get your product fast and quality spot on, absolute blessing.
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  • Sep 20, 2020
    Verified Buyer
    It has been good so far, but I thought I bought authentic replacements.
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  • Sep 16, 2020
    Verified Buyer
    Installed as expected. Functioned just as the originals from HP. Very satisfied.
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  • Great to find ink for my old HP printer.
    May 3, 2020
    Verified Buyer
    Great to find ink for my old HP printer.
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  • Mar 23, 2020
    Verified Buyer
    This is the 2nd time I've ordered refills from CompAndSave.com. In my opinion their refill cartridge is just as good as buying a new cartridge - and a lot less expensive. I was cautious at first but I haven't had any problems since using their refills for my HP Inkjet printer. They're product is a reliable substitute.
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